Ask what would change it
"What would show this is wrong?"
Socratic, sharpened by modern work · Popper (falsifiability)
If nothing could ever count against a claim, it isn't telling you much. Ask what evidence would change the speaker's mind, including your own.
Socrates: 'One of those who would be glad to be refuted if I say anything untrue… just as glad, mind you, to be refuted as to refute.' (458a)
Karl Popper argued a claim is scientific only if some possible evidence could prove it wrong (falsifiability). Socrates gives the attitude, being glad to be refuted; Popper gives the test, naming what would refute it.